Louisiana is crossed east-west by two major interstates , I-20 in the north and I-10 in the south. New Orleans is the hub, traversed by I-10 and served by I-55 and I-59 from Mississippi. I-49 sweeps across southeast to northwest, connecting Cajun country with the north.

The international airport is in New Orleans; regional airlines serve the rest of the state and surrounding areas. Amtrak trains link New Orleans with New York, Chicago and Memphis, and Los Angeles via Lafayette. Greyhound buses connect the major towns with the rest of the country, and are supplemented by smaller local lines. In addition to the Mississippi's bridges and causeways, ferries cross the river at New Orleans, St Francisville in Cajun country, and at various points along the River Road to Baton Rouge.

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